Tierney ("News Radio," "The Good Wife") will make her Broadway debut opposite Academy Award winner Hanks. She will portray McAlary's wife Alice. Vance (Fences, Six Degrees of Separation) will portray McAlary's editor, Hap Hairston.
Tony Award-winning director George C. Wolfe will helm the production that will officially open April 1 for a limited engagement. Tickets are currently on sale through May 19.
Ephron, the late writer-director known for the screenplays to "Sleepless in Seattle," "When Harry Met Sally" and "Heartburn," authored the play about McAlary, who was a columnist for the New York Post and the Daily News.
The cast will also feature Peter Scolari (Sly Fox, Hairspray) as columnist Michael Daly, Richard Masur ("Risky Business," "And the Band Played On") as editor Jerry Nachman/editor Stanley Joyce, Christopher McDonald ("Thelma and Louise," Chicago) as lawyer Eddie Hayes, Peter Gerety ("Flight," "The Good Wife") as editor John Cotter, Michael Gaston (A Day in the Death of Joe Egg, "Mad Men") as columnist Jim Dwyer, newcomer Dustyn Gulledge as Dino Tortoricci, Deirdre Lovejoy ("The Wire," How I Learned to Drive) as reporter Louise Imerman/editor Debbie Krenek, Danny Mastrogiorgio (Golden Boy, Contact) as reporter Bob Drury and Stephen Tyrone Williams (Burning, My Children! My Africa!) as Abner Louima.
Lucky Guy is characterized as "a new play about the scandal- and graffiti-ridden New York of the 1980s, as told through the story of the charismatic and controversial tabloid columnist Mike McAlary. From his sensational reporting of New York’s major police corruption to the libel suit that nearly ended his career, the play dramatizes the story of McAlary's meteoric rise, fall and rise again, ending with his coverage of the Abner Louima case for which he won the Pulitzer Prize, shortly before his untimely death on Christmas Day, 1998."