Under the direction of Bartlett Sher, Clarke played the role of Clara Johnson in the Broadway production and first national touring company of The Light in the Piazza, as well as the Long Wharf Theatre's production of Craig Lucas' Prayer for My Enemy as Marianne. Clarke played Glinda for almost two years before playing the role on the national tour. Her other regional credits include TUTS Houston's Anything Goes.
According to producers, "Long before Dorothy drops in, two other girls meet in the land of Oz. One – born with emerald green skin – is smart, fiery and misunderstood. The other is beautiful, ambitious and very popular. Wicked tells the story of their remarkable odyssey, how these two unlikely friends grow to become the Wicked Witch of the West and Glinda the Good."
There are currently seven productions of Wicked running worldwide — New York, London, Japan, Holland, Seoul and two concurrent North American national tours.