The chat show, which airs Sunday-Thursday, is broadcast at 11 PM ET; check local listings. In addition to LuPone, the program will also feature Billy Eichner.
Upcoming guests also include Brandi Glanville and Hoda Kotb (Jan. 21), Kristen Johnston and Luke Perry (Jan. 22) and Kimora Lee Simmons and Liam McIntyre (Jan. 24).
LuPone is a Tony Award winner for her performances in Evita and Gypsy and an Olivier winner for her work in Les Miserables and The Cradle Will Rock. LuPone is also among headliners on the 2013 Playbill Broadway On the High Seas Cruise in summer 2013.