The 130-minute film, directed by John Wells, is set to premiere in theatres nationwide Dec. 25. It will be part of the gala screenings at the festival, which runs Sept. 5-15.
The darkly comic drama is a large ensemble piece (with three sisters at its core) set in a rambling house in Oklahoma. Two-time Tony Award winner Letts ( Who's Afraid of Virginia Woolf?) also penned the screenplay.
Oscar winner Roberts ("The Normal Heart," "Erin Brockovich") plays Barbara, the oldest Weston daughter, with Streep ("The Devil Wears Prada," "The Iron Lady") as cancer-stricken drug addict Violet Weston.
The cast also features Sam Shepard ( Heartless), Oscar nominee Juliette Lewis, Ewan McGregor (West End's Little Malcolm and His Struggle Against the Eunuchs, "Moulin Rouge"), Olivier Award winner Benedict Cumberbatch ( Frankenstein, "Sherlock"), Tony nominee Margo Martindale ( Cat on a Hot Tin Roof), Oscar winner Chris Cooper ("Adaptation"), Dermot Mulroney ("My Best Friend's Wedding") and Oscar nominee Abigail Breslin ( The Miracle Worker, "Little Miss Sunshine").
The Weinstein Company film is a Jean Doumanian/Smokehouse production produced by George Clooney and Grant Heslov, Jean Doumanian and Steve Traxler. Claire Rudnick Polstein is the executive producer. View the trailer below: