Tony Award-winning director George C. Wolfe will helm the production that will begin previews March 1 and officially open April 1 for a limited engagement through June 16.
Ephron, the late writer-director known for the screenplays to "Sleepless in Seattle," "When Harry Met Sally" and "Heartburn," authored the play about McAlary, who was a columnist for the New York Post and the Daily News.
The cast is led by Hanks as late writer Mike McAlary, Maura Tierney ("News Radio," "The Good Wife") as McAlary's wife Alice, and two-time Tony nominee Courtney B. Vance (Fences, Six Degrees of Separation) as McAlary's editor, Hap Hairston.
The cast will also feature Peter Scolari (Sly Fox, Hairspray) as columnist Michael Daly, Richard Masur ("Risky Business," "And the Band Played On") as editor Jerry Nachman/editor Stanley Joyce, Brian Dykstra (Red, Selling Out) as policeman Brian O'Regan, Christopher McDonald ("Thelma and Louise," Chicago) as lawyer Eddie Hayes, Peter Gerety ("Flight," "The Good Wife") as editor John Cotter, Michael Gaston (A Day in the Death of Joe Egg, "Mad Men") as columnist Jim Dwyer, newcomer Dustyn Gulledge as Dino Tortoricci, Deirdre Lovejoy ("The Wire," How I Learned to Drive) as reporter Louise Imerman/editor Debbie Krenek, Danny Mastrogiorgio (Golden Boy, Contact) as reporter Bob Drury, Stephen Tyrone Williams (Burning, My Children! My Africa!) as Abner Louima, as well as Paula Jon De Rose, Joe Forbrich, Tom Hammond and Marc Damon Johnson.
Lucky Guy will have scenic design by David Rockwell, costume design by Toni-Leslie James, sound design by Scott Lehrer, and lighting design by Jules Fisher and Peggy Eisenhauer. Projection design is by batwin + robin productions.
Hanks' numerous screen appearances include "Sleepless in Seattle," "Philadelphia," "Forrest Gump," "Cast Away," "Saving Private Ryan," "That Thing You Do" and "Cloud Atlas."
The Broadway production is produced by Colin Callender, Roy Furman, Arielle Tepper Madover, Roger and William Berlind, Stacey Mindich, Robert Cole and Frederick Zollo, David Mirvish, Daryl Roth, James D. Stern/Douglas L. Meyer, Scott and Brian Zeilinger, in association with Sonia Friedman Productions and The Shubert Organization.
For tickets visit Telecharge.com.