Directed by Greg Leaming, performances will continue through Feb. 27 at the Sarasota venue.
Other Desert Cities, a 2012 Pulitzer Prize finalist, had its Off-Broadway premiere in January 2011 and transferred to Broadway in November 2011.
The cast for the Asolo staging will include Lauren Klein, Lucy Lavely, J. Kenneth Campbell, Benjamin Williamson and Carolyn Michel.
"Former actor-turned-ambassador, Republican Party bigwig Lyman Wyeth and his wife, Polly, live a picturesque life in their very own affluent exile – the Palm Springs Desert," according to press notes. "When their daughter, left-winged Brooke, returns home during Christmas of 2004 for the first time in six years, she reveals that she has written a tell-all memoir that discloses the family’s controversial past, including one very painful incident. This shocking announcement sends the Wyeth family down an emotional spiral where they are forced to revisit and ultimately heal their wounds from the past. Polly’s recovering alcoholic sister, Silda, and Brooke’s TV producer brother, Trip, complete this holiday family reunion."