DeVito starred in a 2012 London engagement of The Sunshine Boys opposite late actor Richard Griffiths, which Sharrock also directed. Griffiths, who died in March at the age of 65, had been announced to repeat his work for the CTG engagement.
DeVito will return to the role of Willie Clark, with Hirsch as Al Lewis.
Additional casting will be announced.
"I'm so excited to be working with Judd again," DeVito said in a statement. "We did a play together 43 years ago and then, of course, did 114 episodes of 'Taxi.' I'm so excited – did I say that already? This is gonna be a total blast."
Hirsch added, "Here we go again ... just like Al and Willie ... I just can't wait."
Hirsch made his Broadway debut in Barefoot in the Park and performed in Lanford Wilson's The Hot l Baltimore and Talley's Folly. He won Tony Awards for I'm Not Rappoport and Conversations with My Father. He won two Emmy Awards for "Taxi."
DeVito won a Golden Globe and an Emmy Award for his portrayal of Louie De Palma in the hit comedy "Taxi." He starred in the film "One Flew Over the Cuckoo's Nest," in a role he also played on stage, as well as "Terms of Endearment," "Matilda," "The War of the Roses" and his current series "It's Always Sunny in Philadelphia."