Epstein has been cast as the Peter Parker/Spider-Man alternate and will play Saturday and Sunday matinee performances beginning Dec. 8 at the Foxwoods Theatre.
Matthew James Thomas, the original alternate for star Reeve Carney, played his final performance Nov. 11 and will be seen in the title role in A.R.T.'s upcoming production of Pippin.
"Spider-Man may be an iconic American hero, but there is a lot of Canadian pride on our production team and we are delighted to welcome another Canuck into the fold," said Spider-Man lead producer Michael Cohl in a statement.
Epstein is a Canadian-born actor and singer best known for playing Craig Manning on "Degrassi," the popular Canadian teen drama that also aired in the U.S. The actor also starred in the first national touring productions of Green Day's American Idiot (Will) and Spring Awakening (Melchior) as well as the Toronto production of Billy Elliot (Tony).
Spider-Man: Turn Off The Dark features music and lyrics by Bono and The Edge, direction by Philip Wm. McKinley and a book co-written by Julie Taymor, Glen Berger and Roberto Aguirre-Sacasa.
Inspired by over 40 years of Marvel comic books, Spider-Man, according to press notes, "follows the story of teenager Peter Parker, whose unremarkable life is turned upside-down when he's bitten by a genetically altered spider and wakes up the next morning clinging to his bedroom ceiling. This bullied science-geek suddenly endowed with incredible powers soon learns, however, that with great power comes great responsibility as villains put both his physical strength and strength of character to the test."