London's Observer reports that Clooney will produce and likely direct the film adaptation of the play; it is unclear whether the Academy Award winner will appear in the film as well.
The paper also says that none of the original London cast will be part of the motion picture.
Clooney will produce the film with Laura Ziskin; playwright Prebble will pen the screenplay.
Enron, British playwright Prebble's timely-as-today's-headlines play about American corporate greed and white-collar crime, did not repeat its London success on Broadway. It played only 22 previews and 16 performances by the end of its 2010 run.
The U.S. debut of Enron featured Norbert Leo Butz, Gregory Itzin, Stephen Kunken and Marin Mazzie as the four principal wrongdoers at the top of the Enron foodchain in Houston. Kunken was Tony Award-nominated for his work as CFO Andy Fastow in the play.
Goold and Prebble revised Enron for Broadway, streamlining the material for U.S. audiences who might have been familiar with elements of the collapse of the ambitious American energy corporation.