The annual event, which benefits cancer research, is held from 8-9 PM ET and is executive-produced by Paltrow and Joel Gallen of Tenth Planet Productions in collaboration with SU2C's production team.
Also scheduled to take part in the telethon are Felicity Huffman (Speed-the-Plow), Maura Tierney (God of Carnage in Dublin), Matt Damon, Michael Douglas, Jessica Biel, Jeremy Renner, Seth Rogen, Emma Stone, Simon Baker, Jordana Brewster, Diem Brown, Dana Delany, Chelsea Handler, Marg Helgenberger, Rashida Jones, Minka Kelly, Joe Manganiello, Jillian Michaels, Masi Oka, Ana Maria Polo, Alison Sweeney, Tom Hanks, Halle Berry, Justin Timberlake, Eric Stonestreet, Ray Romano, Max Greenfield, Stacy Keibler, Rocco DiSpirito, Ethan Zohn, Gabrielle Douglas, Missy Franklin and SU2C co-founder Katie Couric.
Performers include Taylor Swift, Coldplay, Alicia Keys and Tim McGraw.
"I'm honored to be working with such talented artists who are lending their voice to SU2C's mission," said Gallen in a previous statement. "As we continue to plan the 2012 show, there's a hopeful energy building that the groundbreaking research we help fund will make an enormous impact in the fight against cancer."
For more information, visit StandUp2Cancer.org.