Hosted by Academy, Grammy, Emmy and Tony Award winner Whoopi Goldberg, the event will be held at Pierre Hotel Feb. 3.
Co-directed by Tony Award winner and Drama League alumnus Michael Mayer with Johanna McKeon, the evening will feature performances of musical selections drawn from Harris' career in theatre, film and television.
Harris will star on Broadway in Hedwig and the Angry Inch, beginning performances March 29. He has also performed on Broadway in Assassins and in the New York Philharmonic production of Company. Harris has been honored with four Emmy Awards: three for his acclaimed hosting of the Tony Awards and another for his guest-starring role on "Glee." He also served as host and producer of the 61st and 65th Primetime Emmy Awards.
The black-tie gala supports The Drama League's educational initiatives for promising young artists.