Kerry Ingram and Sophia Kiely will be replaced by Isobelle Molloy (currently playing Amanda Thripp) and Jade Marner from mid-April. They will join Cleo Demetriou and Eleanor Worthington Cox, who continue in the role.
Hayley Canham will also join the company in the role of Matilda from mid-August.
In adult roles, Hayley Flaherty and Steve Furst will take over from Lauren Ward and Paul Kaye, respectively, as Miss Honey and Mr. Wormwood beginning performances April 17.
Bertie Carvel will continue as Miss Trunchbull through July 1, and Josie Walker remains as Mrs. Wormwood along with the rest of the current adult cast.