Directed by Aaron Posner, performances are scheduled for April 2-28 in the MAX Theatre.
The two-hander will feature James Gardiner (Chess, [title of show]) and Erin Weaver (Xanadu).
"From first date to final goodbye," The Last Five Years, according to the Signature, "chronicles the highs and lows of modern marriage in an intimate, honest and richly moving musical portrait. Through the course of 14 songs, rising novelist Jamie and struggling actress Cathy separately tell their own account of their five-year relationship."
The musical is currently enjoying an Off-Broadway revival at Second Stage Theater.
Performances at the Signature will be Tuesday and Wednesday at 7:30 PM, Thursday-Saturday at 8 PM, Sunday at 7 PM and Saturday and Sunday at 2 PM.
Tickets start at $40 and are available by phone at (703) 573-SEAT, online at signature-theatre.org, or in person at the Signature Box Office at 4200 Campbell Avenue in Shirlington.