Izzard (A Day in the Death of Joe Egg), Lumley (La Bête), Williams (Bengal Tiger at the Baghdad Zoo) and Python members John Cleese, Terry Gilliam, Eric Idle and Michael Palin will join Kate Beckinsale, Simon Pegg and Sanjeev Bhaskar.
The project, which is slated to begin shooting March 24 in London, casts Pegg as a disillusioned schoolteacher, who is given the chance to do anything he wishes from a group of aliens watching from space.
The aliens will be voiced by director Jones and his fellow Python members Cleese, Gilliam, Idle and Palin, and Williams will voice a dog named Dennis.
Ben Timlett and Bill Jones produce the film with Mike Medavoy and Chris Chesser as executive producers. Jim Acheson will design costumes, sets and the aliens.
Holed up in a seedy motel on the edge of the Mojave Desert, two former lovers unpack the deep secrets and dark desires of their tangled relationship, passionately tearing each other apart. Led by director Daniel Aukin (Back Back Back at MTC, 4,000 Miles), Tony winner Nina Arianda (Venus in Fur at MTC, Born Yesterday) and Sam Rockwell (A Behanding in Spokane, The Way Way Back) bring an explosive intensity to Sam Shepard’s (Buried Child, True West) landmark myth of the new Wild West.