Snoop Lion and Zachary Levi host the evening, which features presenters Jessica Alba, Marlon Wayans, Adam Scott, Norman Reedus and Steven Yeun, among others.
Samuel L. Jackson (The Mountaintop) will also appear at "VGA TEN," which features musical performances by Linkin Park, Tenacious D, Gustavo Santaolalla and more.
Harris' Broadway credits include Assassins, Proof and Cabaret as well as the L.A. company of Rent, the Reprise! and New York Philharmonic productions of Company and Sweeney Todd and the London mounting of tick, tick...BOOM! Harris is also well known for his television work on "How I Met Your Mother" and "Doogie Howser, M.D." He has also hosted the Tony Awards three times.
The show will simulcast on MTV 2, MTV Tr3s, Xbox LIVE, Spike.com and GameTrailers.com.