The production will be directed by Tony Award winner Michael Mayer (Spring Awakening, American Idiot).
"I am simultaneously ecstatic and terrified to be stepping into Hedwig's heels," Harris said in a statement. "It is truly a once-in-a-lifetime role and I can't wait to begin the journey."
Hedwig and the Angry Inch is a dramatic musical comedy about a fictional rock 'n' roll band fronted by a transgender singer. The production began Off Off-Broadway at Westbeth and then ran over two years at the Jane Street Theatre beginning in February 1998. The musical won the Outer Critics Circle Award for Best Off-Broadway Musical, and both John Cameron Mitchell and Stephen Trask won Obies. Hedwig and the Angry Inch won a 1998 New York Magazine Award and Entertainment Weekly's "Soundtrack of the Year" Award.
John Cameron Mitchell, who wrote the book and starred in the original stage and film productions of Hedwig, said in a statement about Harris playing the title role, "Who better to pass the wig to but the finest entertainer of his generation?" Composer Stephen Trask said, "It's like you're putting together a fantasy rock band and Paul McCartney agrees to play bass."
Harris has performed on Broadway in Assassins and in the New York Philharmonic production of Company. He is a three-time Emmy Award winner for his guest-starring role on "Glee" and as host of the 63rd and 65th Annual Tony Awards. He also served as host and producer of the 61st Primetime Emmy Awards, as well as the 66th and 67th Annual Tony Awards. Harris will next host and produce the upcoming 65th Primetime Emmy Awards.
The remaining creative team members, additional casting and the theatre will be announced at a later date.