Kate Whoriskey directs. Previews will begin Jan. 24, 2012, toward a Feb. 13 opening night.
Butz won Tonys for his work in Dirty Rotten Scoundrels and Catch Me If You Can. Reaser appeared in "Twilight" and "Grey's Anatomy."
Acccording to Second Stage Theatre, How I Learned to Drive "explores the complex relationship between Li'l Bit (Reaser) and her Uncle Peck (Butz), as a series of driving lessons progresses from innocence to something much darker. Told with surprising wit, Paula Vogel's acclaimed play is returning to New York City for the first time since its world premiere 15 years ago."
Reaser earned an Independent Spirit Award nomination for Best Actress for her role in the drama "Sweet Land," and also received an Emmy nomination for her guest spot as Ava on "Grey’s Anatomy." She is matriarch of the Cullen clan in the popular "Twilight" films.
Vogel's plays include The Baltimore Waltz, Desdemona: A Play About a Handkerchief, The Oldest Profession, And Baby Makes Seven, Hot 'N Throbbing, The Mineola Twins, The Long Christmas Ride Home and Civil War Christmas, among others.
Performances play Second Stage's Tony Kiser Theatre (305 West 43rd Street). For tickets or more information, visit www.2ST.com.