LuPone will play Lorraine Galassini, the mother of Army Captain Nicole Galassini, played on the series by Kellie Martin, who also appeared alongside LuPone in the ABC drama "Life Goes On."
Chlumsky, who was seen Off-Broadway in So Help Me God, will appear as Jessica Anderson, an army wife who learns that her husband is severely injured in Afghanistan.
LuPone, most recently seen on Broadway in An Evening With Patti LuPone and Mandy Patinkin, is a two-time Tony Award winner for her performances in Evita and Gypsy. She was nominated for her performances in Women on the Verge of a Nervous Breakdown, Sweeney Todd, Anything Goes and The Robber Bridegroom.
"Army Wives" airs Sunday nights at 9 PM ET on Lifetime.