The agreement, which runs through 2016, launches July 21 with The Lady with The Torch, which continues through Aug. 2.
"I love 54 Below," said LuPone in a statement. "It was an honor to launch this beautiful supper club when it first opened its doors two ago and it always feels like a homecoming when I return."
"We are thrilled to have entered into this multi-year collaboration with Patti LuPone," added Richard Frankel, an owner of 54 Below. "This agreement to grace our audiences with eight weeks of performances in the next two years is a testament to Patti's power as an artist and the devoted audience that wants to see her. In the two years we have been open, Patti has played five engagements at 54 Below including her initial run that opened the room. Each engagement has been an event prompting sold-out houses, rave reviews and audiences delighted to be in the same, gorgeous and intimate room with one of the greatest artists of our time."
LuPone is a Tony Award winner for her performances in Evita and Gypsy and an Olivier winner for her work in Les Miserables and The Cradle Will Rock. Read more about the award-winning artist's career in the Playbill Vault.