Prince succeeds Emmy Award-winning "Glee" star Jane Lynch, who played her final performance July 14.
"I had the wonderful experience of working with Faith Prince on Falsettoland and I am thrilled that she will be joining the Annie company as Hannigan, a role she was born to play," said director James Lapine in an earlier statement.
Prince won the Tony Award in 1992 for her performance in Guys and Dolls. She has also been nominated for her performances in Jerome Robbins' Broadway, Bells are Ringing and A Catered Affair. Her other Broadway credits include Nick & Nora, What's Wrong With This Picture?, The King and I, Little Me, James Joyce's The Dead and The Little Mermaid, among others.
The revival of Annie, directed by Lapine and choreographed by Tony Award winner Andy Blankenbuehler, opened on Broadway Nov. 8, 2012, at the Palace Theatre.
Annie features a Tony Award-winning book by Thomas Meehan. The original production earned seven Tony Awards including Best Musical and Best Score for its 1977 debut starring Andrea McArdle in the title role. The production ran for 2,377 performances and has enjoyed numerous national tours and a 1997 Broadway revival, which went unrecorded.
For more about the new Broadway production, visit AnnieTheMusical.com.