The evening boasted the talents of Tony winner Beth Leavel, The Broadway Dolls, Tony winner Christian Borle, Ward Billeisen, Rachel Dratch, Max von Essen, Richard H. Blake, David Patrick Kelly, Kristine Reese, Julie Reiber, Coleen Sexton, Jennifer Hope Wills, Tony Yazbeck, Broadway Inspirational Voices and over 50 other Broadway and Off-Broadway performers.
Music arrangements are by Ryan Fielding Garrett and Drew Overcash.
During the last 50 years, "St. Jude Children’s Research Hospital has remained focused on pioneering research and advance treatments that will one day cure childhood cancer and other deadly diseases. Since opening in 1962 by late entertainer and hospital founder Danny Thomas, its researchers and doctors have helped push overall survival rates of childhood cancer from 20 to 80 percent. St. Jude Children’s Research Hospital is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. It is also a leader in the research and treatment of blood disorders and infectious diseases in children."