Michael Sexton will direct his work, which has been adapted from Shakespeare's Richard III and Henry VI. Performances will take place Feb. 25-27 at the Theatre at St. Clement's.
The cast will include Randy Harrison (Wicked, "Queer As Folk"), as well as Kate Forbes (Othello), Craig Baldwin, Jacob Fishel, Jason Butler Harner, Robert Stanton, Michael Stewart Allen and David Townsend.
According to the Red Bull, Margaret, A Tyger's Heart "will explore the journey of one of Shakespeare’s most remarkable characters [Margaret of Anjou], a woman of astonishing variety with an extraordinary arc over four history plays."
Kathleen Chalfant and Michael Stuhlbarg will be special guests at the Feb. 26 performance.