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Joseph Gordon-Levitt, a Golden Globe nominee for his performances in "50/50" and "(500) Days of Summer," is developing the project and will likely play nerdy plant-shop worker Seymour, according to The Hollywood Reporter.
The original 1960 film version of "Little Shop of Horrors" was directed by Roger Corman.
The 1986 remake, directed by Frank Oz, was based on the 1982 Off-Broadway musical, which features a score by Newsies Tony nominee Alan Menken and the late Howard Ashman. Ellen Greene, preserving her stage role, and Rick Moranis starred in the film musical.
Aguirre-Sacasa confirmed to Playbill.com that the project is a remake of the movie musical.
Aguirre-Sacasa, who joined the Spider-Man creative team to revise the musical's original script, has also penned revisions to the 1966 Charles Strouse-Lee Adams musical It's a Bird…It's a Plane...It's Superman. The playwright has written Spider-Man stories for Marvel Comics and penned the plays Good Boys and True, Based on a Totally True Story, The Mystery Plays and The Muckle Man.