The film, from Blumhouse, Smart Entertainment and Nuyorican Productions, will be directed by Rob Cohen from a script by Barbara Curry.
Lopez will play a single mother who finds herself attracted to the teenage boy who moves in next door and befriends her son. Chenoweth would play Lopez's best friend.
"The Boy Next Door," which is slated to begin shooting this fall, will be produced by Jason Blum, Elaine Goldsmith-Thomas, Benny Medina and John Jacobs with Zac Unterman serving as an executive producer.
Chenoweth won the Tony Award in 1999 for her performance in You're A Good Man, Charlie Brown. She was nominated in 2004 for her performance in Wicked and has also been seen on Broadway in Steel Pier, Epic Proportions, The Apple Tree and Promises, Promises. The Emmy-winning actress is also known for her film and television work and was recently seen in the ABC series "GCB."