Patty Duke was originally announced to headline the tour, which is to begin at Fort Lauderdale's Parker Playhouse on Oct. 18, where it will stay for three weeks. No reason for her departure was given.
Harper, best known for "The Mary Tyler Moore Show" and "Rhoda," has appeared on the stage in The Tale of the Allergist's Wife and All Under Heaven.
The tour will play for 26-plus weeks, through May 14, 2006, and will make stops in Detroit, Chicago, Washington, D.C., Pittsburgh, Houston, Philadelphia, St. Paul, Tempe, AZ, Hartford, Cincinnati, Columbus, Milwaukee and Toronto. Other cities and dates will be announced in the future.
Scott Schwartz will repeat his directorial duties.
During the 90-minute, intermissionless show, Harper will appear in heavy makeup to make her resemble former Israeli Prime Minister Golda Meir, and play 30 characters and never leave the stage.
Golda became the longest-running one-woman show in Broadway history on Oct. 3, 2004.