The two-person play by Marsha Norman, who penned the book to The Color Purple (on which Winfrey was lead producer) and is currently represented with Broadway's The Bridges of Madison County, would cast Winfrey as a mother struggling to stop her daughter from committing suicide.
Tony winner George C. Wolfe (Lucky Guy) would direct the production, which is aiming for a Broadway bow in the 2015-16 season, according to theatre executives.
Lead producer Scott Sanders confirmed that he was in discussions with Winfrey to make her Broadway debut, but declined to discuss further details.
"Oprah has had a longstanding desire to act on Broadway," Sanders told the Times. "She understands how unique and challenging performing live on stage will be as an actress. She and I have been looking at a number of plays and roles in order to find material and a character that truly resonate with her. We've recently read something that we're both excited about but are not yet ready to officially announce the specifics."
'night, Mother opened on Broadway in March 1983 and starred Kathy Bathes and Anne Pitoniak. The production was nominated for four Tony Awards, including Best Play, and took home the 1983 Pulitzer Prize for Drama. A revival bowed on Broadway in 2004, starring Edie Falco and Brenda Blethyn.