Joining Tony and Emmy winner John Lithgow will be two-time Drama Desk Award nominee Margaret Colin (“Gossip Girl,” MTC’s Defiance) and four-time Tony Award winner Boyd Gaines (Gypsy, Contact). Tony Award winner Daniel Sullivan directs.

Colin will play Susan Alsop, wife of Joseph Alsop, to be played by Lithgow. Gaines will play Stewart Alsop, brother of Joseph.

"Columnists are kings in midcentury America and Joseph Alsop (Tony and Emmy Award winner John Lithgow) wears the crown," according to production notes. "Joe is beloved, feared and courted in equal measure by the Washington political world at whose center he sits. But as the ’60s dawn and America undergoes dizzying change, the intense political drama Joe is embroiled in becomes deeply personal as well."

The creative team includes John Lee Beatty (scenic design), Jess Goldstein (costume design), Kenneth Posner (lighting design), John Gromada (original music, sound design), Rocco DiSanti (projection design) and Charles LaPointe (hair and wig design).

Colin returns to MTC after appearing in Defiance, for which she received a Drama Desk nomination. She also appeared in MTC’s acclaimed Off-Broadway productions of Pschopathia Sexualis and Sight Unseen. Her other theatrical credits include Arcadia, Old Acquaintances, A Day in the Death of Joe Egg and Jackie. Gaines has received four Tony Awards: Gypsy (2008), Contact (2000), She Loves Me (1994) and The Heidi Chronicles (1989). In addition, he appeared in the Broadway productions of Driving Miss Daisy, Journey’s End and Twelve Angry Men.

MTC’s Samuel J. Friedman Theatre is located at 261 West 47th Street. Tickets, priced $57-$116, are available by calling Telecharge at  (212) 239-6200, online by visiting www.Telecharge.com or by visiting the Samuel J. Friedman Theatre Box Office.

For more information visit www.ManhattanTheatreClub.com.