Egan's official website says that she and Harris play the parents of a young girl who is kidnapped on the new series, which airs Friday nights on CBS. The episode, titled "Prime Suspect," will be broadcast Feb. 18. The TV Guide website describes the episode thusly: "A six-year-old girl is kidnapped by a pair of clowns hired to perform at her birthday party shortly after the celebration ends. The girl's dad (Harris) is a brilliant mathematician who is working on a complex problem and refuses to cooperate with the police, saying that he can get his daughter back without their help. This leads Charlie to believe that the kidnappers are after something that the missing girl's father is working on. Back at home, Alan decides to sell his house."

"Numb3rs," according to the CBS website, features Rob Morrow as "FBI agent Don Eppes, who recruits his mathematical genius brother, Charlie (David Krumholtz), to help the Bureau solve a wide range of challenging crimes in Los Angeles. From two very different perspectives, the brothers take on the most confounding criminal cases, aided by Don's partner, Terry Lake (Sabrina Lloyd), and new FBI recruit David Sinclair (Alimi Ballard). Although their father, Alan (Judd Hirsch), is pleased to see his sons working together, he fears their competitive nature will lead to trouble. Charlie's colleague, physicist Dr. Larry Fleinhardt (Peter MacNicol), urges Charlie to focus more on his university studies than on FBI business. Inspired by actual events, 'Numb3rs' depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions."

Neil Patrick Harris, most recently on Broadway in Assassins, also portrayed the Emcee in the Tony-winning revival of Cabaret. His other stage appearances include the New York company of Proof, the L.A. company of Rent and the Reprise! production of Sweeney Todd. His screen credits include "Undercover Brother," "Doogie Howser, M.D.," "Stark Raving Mad" and "Joan of Arc."

Susan Egan received Tony and Drama Desk Award nominations for her work in Beauty and the Beast, and her other theatre credits include Thoroughly Modern Millie, Cabaret, Triumph of Love, Putting It Together and Hello Again. Her debut solo recording was titled "So Far" and includes tunes from her many theatrical outings. Her new recording is titled "Coffee House."

Visit www.cbs.com for more information.