Oscar winner Jonathan Demme directed the pilot that was written by Susanna Grant.
In the hour-long drama that is set for Friday nights at 8 PM ET, Martindale will play the assistant to Michael (Wilson), a competitive surgeon whose life changes when his ex-wife (Ehle) dies, but comes back to teach him life lessons. Martindale's character, Rita, helps Michael get through the day.
Ehle won the Tony Award in 2000 for her work in The Real Thing and again in 2007 for her performance in The Coast of Utopia trilogy.
Wilson received Tony nominations for his performances in Oklahoma! and The Full Monty, and Martindale is known for her Tony-nominated performance in Cat on a Hot Tin Roof.
An initial air date for "A Gifted Man" has not yet been announced.