"Happily Divorced," written by Drescher and Peter Marc Jacobson, centers around Los Angeles florist Fran (Drescher) and is inspired by the actress' real-life former marriage and subsequent divorce.
After Fran finds out her realtor husband of 18 years, played by John Michael Higgins (La Bête), is gay, she juggles her new relationships while still sharing the same house. The cast also includes Tony Award winner Rita Moreno (The Ritz), Tichina Arnold, Robert Walden and Valente Rodriguez.
Shaughnessy will play a man that both Fran and her ex-husband want to date.
Shaughnessy has been seen on Broadway in Urinetown and most recently appeared on stage at North Shore Music Theatre in My Fair Lady.
"Happily Divorced" airs Wednesday nights at 10:30 PM ET on TV Land.