Collette, a Tony and Academy Award nominee, will join John Krasinski ("The Office"), Cheryl Hines ("Curb Your Enthusiasm"), and Maya Rudolph ("SNL") in Mendes' upcoming comedy chronicling the experiences of a young couple who journey across America in search of "home" as they expect their first child, according to the Hollywood Reporter.

As previously reported, "A Heartbreaking Work of Staggering Genius" author Dave Eggers and his wife Vendela Vida, a novelist and editor of "The Believer" magazine, have penned the original screenplay. Ed Saxon, Marc Turtletaub, Peter Saraf of Big Beach Films, and Mendes' Neat Street Productions will produce the film, tentatively titled "This Must Be the Place."

Filming is set to begin in Connecticut later this month.

Collette earned a 2000 Tony nomination for her work as Queenie in Michael John LaChiusa's The Wild Party, which marked her Broadway debut. The 1999 hit "The Sixth Sense" garnered Collette an Academy Award nomination. Her film credits also include "Little Miss Sunshine," "Evening," "Muriel's Wedding," "Velvet Goldmine" and "Clockwatchers."

Sam Mendes made his Broadway directorial debut with the critically acclaimed revival of Cabaret, which earned the 1998 Tony for Best Revival of a Musical. As artistic director of the Donmar Warehouse, Mendes earned Tony Awards for presenting the Broadway productions of Take Me Out and The Real Thing. He most recently staged the 2003 revival of Gypsy starring Bernadette Peters. For his directorial film debut, Mendes received the Academy Award for Best Director on "American Beauty."