Universal has backed the Working Title Films production, which focuses on the life and love of physicist Stephen Hawking.
The movie, penned by Anthony McCarten, is inspired by Jane Hawking's memoir "Travelling to Infinity: My Life with Stephen," which tells the story of Hawking's love affair with Jane Wilde, whom he fell in love with at Cambridge University in the 1960s.
Redmayne and Jones join a cast that also includes David Thewlis, Emily Watson, Charlie Cox, Simon McBurney, Maxine Peake and Harry Lloyd.
Filming will take place in Cambridge and at other locations in the U.K. "The Theory of Everything" is produced by Tim Bevan and Eric Fellner, and Lisa Bruce and McCarten.