Lucy Prebble's The Effect, helmed by David Cromer, is making its U.S. debut at Off-Broadway's Barrow Street Theatre. It officially opened March 16.
The cast features Kati Brazda (Our Town), Susannah Flood (Tribes, Love and Information), George Demas, Carter Hudson (The Substance of Fire) and Steve Key (August: Osage County).
The play follows the relationship between psychology student Connie and "charming drifter" Tristan. According to production notes, "Both have signed up to a clinical trial for a new antidepressant super-drug. Sealed off from the outside world, the attraction between Connie and Tristan turns into deeper feelings as their doses get stronger. They've been warned of side effects – can they trust their feelings, or is this just a chemical romance? As the trial's overseeing physician and her superior contend with the illicit relationship of their charges, they become increasingly conflicted about the ethical implications of their work. It's soon clear that neither is objective about the complex issues that surround them."