McDormand will make her animated voiceover debut as an animal control officer, who sets out to capture Alex the lion (Stiller), Marty the zebra (Rock), Melman the giraffe (Schwimmer) and Gloria the hippo (Pinkett Smith). The animals are trying to join a traveling circus in their quest to get back to New York.
Eric Darnell, who has co-directed and co-written the series, will direct this film from a script by Noah Baumbach.
McDormand, who will appear on Broadway this February in the Manhattan Theatre Club production of Good People, received an Academy Award for "Fargo," additional nominations for "Mississippi Burning," "Almost Famous," "North Country" and "Fargo," and a Tony Award nomination for A Streetcar Named Desire.
Comedian and actor Rock ("Grown-Ups," "Death at a Funeral," the documentary "Good Hair") will make his Broadway debut this spring in The Motherf**ker with the Hat.
Stiller (the "Meet the Parents" and "Night at the Museum" films) will also appear on Broadway in the spring in the revival of The House of Blue Leaves, a show he appeared in previously on Broadway in 1986.
Schwimmer, known for the long-running sitcom "Friends," regularly appears at Chicago's Lookingglass Theatre Company, where he is a founding member. The theatre recently produced Trust, a play he co-wrote with Andy Bellin.
Pinkett Smith ("Hawthorne," "The Matrix" films) was a producer of the recent Broadway musical Fela!