The pre-taped segment will include a scene from the show and interviews with the creative team about Lost's 31-year-old composer Jessica Grace Wing, who died of colon cancer on July 19. The spooky operatic musical was written by Wing and lyricist-librettist Kirk Wood Bromley and is a production of Bromley's Inverse Theatre Company. The show has attracted considerable press—include a lengthy New York Times story—due to the sad fate of Wing. She was working on the project until the last; the final song was composed the day before she passed away.

Lost is a modern take on the Hansel and Gretel fairy tale. Here, the children are abandoned by their father in the Great Smokey Mountains and quickly adopted by a witch, Mamba, and her scientist husband, Laborious. Mamba and Laborious have lived in the forest for four centuries, keeping themselves alive by saving the lost children of various dark chapters in American history and then harvesting their limbs and organs. Among the kids held in suspended enslavement by the couple's alchemic surgery are Ivy, a girl nearly killed by the Salem Witch Trials and Silas, a soldier left to die on a Civil War battle field.

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