The comedy series will be inspired by Leguizamo's professional, personal and family life in New York City. Search is underway for a writer to pen the project.
Leguizamo will executive produce with his manager Jeff Golenberg as well as David Hoberman and Todd Lieberman.
Leguizamo is currently touring the country in his Drama Desk Award-winning performance of Ghetto Klown, which was seen on Broadway last year. The performer was nominated for a Tony Award for his performance in Freak, and his one-man show Sexaholix was nominated in 2002 for Special Theatrical Event. He has also appeared on Broadway in American Buffalo.