Directed by Trip Cullman, the cast will feature Halley Feiffer, Daniel Eric Gold, Carter Hudson, John Noble and Charlayne Woodard.

"Isaac Geldhart, the volatile and brilliant patriarch of his family publishing house, is stubbornly holding on to his place at the head of the company while his three children try to convince him to publish a desperately needed best-seller," according to press notes. "Faced with a changing literary landscape and potential takeover of the company, the Geldhart children must either come to terms with their father and band together or break apart and forfeit the legacy he risked everything to build. Articulate and blessed with a lifesaving and cutting sense of humor, Isaac fights like a man with nothing to lose."

The upcoming production will also have scenic design by Anna Louizos, costume design by Emily Rebholz, lighting design by Peter Kaczorowski and sound design by Jill BC Du Boff. The production stage manager is Lori-Ann Zepp.

The Substance of Fire premiered at Playwrights Horizons in 1991 in a production directed by Daniel Sullivan and starring Ron Rifkin and Sarah Jessica Parker. It subsequently transferred to Lincoln Center’s Mitzi Newhouse Theater and was also made into a 1996 film.

Tickets are available through 2ST.com or by calling the box office at (212) 246-4422. All performances are staged at Second Stage’s Tony Kiser Theatre, 305 West 43rd Street (just west of Eighth Avenue).