Directed by Edward Hall, the production will officially open March 11. Performances continue through April 5. The cast will be headed by Tony and Emmy winner Edward Herrmann (Mrs. Warren's Profession, "Gilmore Girls," "The Practice," "Eleanor and Franklin") as Pope Urban VIII and Drama Desk winner Jay O. Sanders (Pygmalion, Stuff Happens, "Revolutionary Road") as Galileo Galilei; with Diego Arciniegas as Bruno; Dermot Crowley as Giovanni Ciampoli, Pope Urban's close counsel; Joe Curnutte as a Senator; Nat DeWolf as a Senator; Jeremiah Kissel as Niccolini; Andy Paris as Johannes Kepler and Francesco Barberini; Joel Rainwater as Castelli; Peter Van Wagner as a Cardinal; and Molly Schreiber as Galileo's daughter, Sister Marie Celeste.

"Inspired by his faith and encouraged by his patron, Cardinal Maffeo Barberini, devout Catholic Galileo Galilei strives to gain a deeper understanding of the scientific truths that explain his world," according to Two Men of Florence press notes. "When the politically ambitious Barberini ascends to become Pope Urban VIII, he comes to realize that Galileo's discoveries threaten to rock his Church's very foundation. The two old friends unexpectedly find themselves on opposing sides of a battle between reason and faith as each comes to realize the personal cost of passionately advocating for their beliefs."

The creative team includes scenic and costume designer Francis O'Connor, lighting designer Ben Ormerod, sound designer Matt McKenzie and composer Simon Slator. Production stage manager is Gail P. Luna; stage manager is Carola Morrone.

The Huntington's mainstage, the Boston University Theatre, is located at 264 Huntington Avenue in Boston, MA. Tickets, priced $20-$82.50, are available by visiting www.huntingtontheatre.org or by calling (617) 266-0800.