Juan Hernandez and Amy Sedaris will leave the cast of The Most Fabulous Story Ever Told , Paul Rudnick's hit retelling of the Judeo- Christian creation story, when it moves into the Minetta Lane Theatre Jan. 29. Replacing them will be, respectively, Jay Goede (Sex and Longing) and Peg Healey.

The rest of the original New York Theatre Workshop cast will remain, including Obie Award winner Joanna Adler (Benita Canova ), Katherine Meisle, Becky Ann Baker (Titanic), Peter Bartlett, Lisa Kron (101 Humiliating Stories ), Orlando Pabotoy and Alan Tudyk (Bunny Bunny ). Healey and Kron are cronies of the Five Lesbian Brothers and appeared together in such Bros. works as The Secretaries and Brides of the Moon.

Meisle joined the cast as Mabel when Jenny Bacon broke a bone in her foot during an early performance, causing the show to delay its opening until Dec. 14. Meisle is a veteran of such Broadway productions as The Rehearsal and London Assurance , both at the Roundabout.

The set design for Fabulous is by Michael Brown, costumes are by Susan Hilferty, lighting design is by Donald Holder with sound by Darron L. West.

In the play, Rudnick ponders what it would be like had God started out by making Adam and Steve, rather than Adam and Eve. Adam and Steve (along with Jane and Mabel) take us on a journey from Mesopotamia to a K Mart on Christmas Eve as they struggle for faith and search for God. Rudnick's comedy made its debut this summer at the Williamstown Theatre Festival. As he did at Williamstown, frequent Rudnick collaborator Christopher Ashley will direct. Rudnick's comedies include Jeffrey, The Naked Eye, Mr. Charles and I Hate Hamlet, as well as scripts for the films "In & Out" and "Addams Family Values."

Call (212) 420-8000 or (212) 307-4100 for more information.

-- By Robert Simonson