Stamos plays Carl, the dentist who is currently dating Emma (Jayma Mays), on the hit Fox musical series. The episode will follow their growing relationship as the glee kids head toward sectionals and deal with their own relationship problems.
Best known for TV appearances on "Full House" and "ER," Stamos has appeared on Broadway in Bye Bye Birdie, Nine, Cabaret and How to Succeed in Business without Really Trying.
"Glee" airs Tuesday evenings at 9 PM ET on Fox.