Scott Ellis directs the work scheduled to open Feb. 22 for a run at the company's midtown home through April 4.

Penned by Beane (The Little Dog Laughed, Xanadu), Mr. & Mrs. Fitch centers on two gossip columnists. "When the social circuit no longer provides any scandalous news, they find that great celebrity can appear out of thin air," according to a release. The new comedy promises "a scathing look at who is in, who is out and who may not even exist at all."

Lithgow was last seen on Broadway in the revival of All My Sons. His stage work also includes Dirty Rotten Scoundrels, Mrs. Farnsworth, The Retreat From Moscow and his Tony Award-winning turns in The Changing Room and Sweet Smell of Success. He recently earned a Golden Globe for his turn on "Dexter." Other credits include "Shrek," "Kinsey," "Terms of Endearment" and "Footloose."

Ehle appeared in The Coast of Utopia, earning her second Tony win for her role in the Tom Stoppard epic. Her first came for her Broadway debut in the 2000 revival of Stoppard's The Real Thing. Other credits include Design for Living, Macbeth and the film "Pride and Prejudice" and "Possession."

The design team features Allen Moyer (scenic), Jeff Mahshie (costume) and Kenneth Posner (lighting). Second Stage next presents the New York premiere of Kristoffer Diaz's The Elaborate Entrance of Chad Deity (April 27-June 20) and Paul Weitz's Trust (summer 2010).

For tickets to Mr. & Mrs. Fitch at Second Stage Theatre, 305 West 43rd Street (off Eighth Avenue), call (212) 246-4422. For more information, visit 2ST.com.