The series, according to HBO, "takes a comic look at the assorted humiliations and rare triumphs of a group of girls in their early 20s.... Hannah, Marnie, Jessa and Shoshanna are trying to figure life out. They've been living in New York for a couple of years, but they're still not sure what they want — from boys, from each other, from themselves. And things aren't getting any clearer."

The cast also features Jemima Kirke ("Tiny Furniture"), Allison Williams ("American Dreams"), Zosia Mamet ("Mad Men") and Adam Driver (Angels in America, HBO's "You Don't Know Jack"). Recurring guest stars include Chris Abbott ("Martha Marcy May Marlene") and Alex Karpovsky ("Tiny Furniture").

Guest stars include Book of Mormon Tony nominee Andrew Rannells, who will make his first appearance April 29, as well as Becky Ann Baker and Peter Scolari as Hannah's parents, Mike Birbiglia, Kathryn Hahn, Michael Imperioli, James LeGros, Richard Masur, Bobby Moynihan, Chris O'Dowd, Lou Taylor Pucci, Jenny Slate and Jorma Taccone.

Dunham, Judd Apatow and Jenni Konner executive produce the show; Bruce Eric Kaplan and Ilene S. Landress co-executive produce.

The pilot episode is described as such: "Hannah (Lena Dunham), a 24-year-old aspiring writer living in New York City, is blindsided when her parents (Becky Ann Baker, Peter Scolari) cut her off financially. Subsequently fired from her unpaid internship, she seeks comfort in Adam (Adam Driver), the eccentric actor she sometimes sleeps with when she can get him to respond to her texts. Meanwhile, Hannah's best friend and Type-A roommate, Marnie (Allison Williams), hosts a dinner party for their bohemian British friend Jessa (Jemima Kirke), who’s returned from god-knows-where to move in with Shoshanna (Zosia Mamet), Jessa's younger, 'Sex and the City'-obsessed cousin." Episode two, which is titled "Vagina Panic," will debut April 22. The third episode, entitled "All Adventurous Women Do," debuts April 29.