The series, which will make its debut in summer 2016, comes from Robert and Michelle King, creators and executive producers of "The Good Wife."
James will play Rochelle, a "medical resident whose father died as the result of a mysterious infection. She and Laurel (Mary Elizabeth Winstead) team up to learn what happened to her father, and protect others from the same fate," according to press notes.
As previously announced, Winstead will star as Laurel, a "young, fresh-faced Hill staffer whose first job in Washington, D.C. leads her to discover two things: The government has stopped working, and alien spawn have come to earth and eaten the brains of a growing number of Congressmen and Hill staffers." Broadway's Aaron Tveit will star as Gareth, the Legislative Director to a top Republican senator.
"We fell in love with Nikki the first time we saw her in The Book of Mormon," said executive producers Robert and Michelle King in a statement. "Her work on ‘The Good Wife’ has only increased our admiration, and we couldn't be more excited that she's joining the cast of 'BrainDead.'"
James won the 2011 Tony Award for Best Featured Actress in a Musical for her role as Nabalungi in the hit Broadway musical The Book of Mormon. She will also appear in a recurring role on "The Good Wife" this season.
"BrainDead" is produced by CBS Television Studios.