Tom Hanks, Billboard.com reports, hosted the first half, which featured appearances by Tom Cruise, "America's Got Talent" performer Jackie Evancho, Josh Groban, Patti LaBelle, Madonna, Dakota Fanning, Beyonce, Diane Sawyer, Halle Berry, Katie Homes, Queen Latifah and Rascal Flatts.
The second portion, hosted by Will Smith and Jada Pinkett, featured Michael Jordan, Jamie Foxx, Stevie Wonder, Jerry Seinfeld, Simon Cowell, Rosie O'Donnell, Dr. Phil, Dr. Oz, Maria Shriver, Kristin Chenoweth, Maya Angelou, Alicia Keys, Stedman Graham, Aretha Franklin and Usher.
After the performances, Winfrey said, "I've never experienced anything like this and I say once again thank you for taking me to a place that's beyond joyous. I'm going to have to process it and look at it on tape to see what actually happened here. It feels like the rapture, so thank you all for that!"
Winfrey's final show airs May 25.