Tony winner Doug Hughes directs the 7 PM performance, a benefit for the Acting Company.

Joining LuPone and Cannavale are Eliza Bald, Tina Benko, Johann Carlo, Helen Cespedes, Christian Conn, Patch Darragh, Stephanie DiMaggio, Robin Galloway, Peter Mark Kendall, Antoinette LaVecchia, Benj Mirman, George Morfogen, Rishi Mutalik, Pamela Nyberg, Angela Pierce, Julia Randall, Jennifer Regan, Mary Lou Rosato, Jose Useche and Brenda Wehle.

"The Rose Tattoo is the story of Serafina, a Louisiana widow who withdraws from the world after her husband's death and expects her daughter to do the same,” said Margot Harley, producer of The Acting Company, in an earlier statement. “One day, a man resembling her late husband comes into her life and unlocks her fiery passion, wit, anger and pride.”

“This is a play of power, humanity and soaring emotion,” added LuPone, a founding alumna of The Acting Company.

Williams' drama, written in 1951 between Streetcar Named Desire and Cat on a Hot Tin Roof, originally starred Maureen Stapleton and Eli Wallach. It has been revived twice on Broadway, in 1966 with Stapleton and Harry Guardino, and 1995 with Mercedes Ruehl and Anthony LaPaglia.

Samuel J. Friedman Theatre is located at 261 West 47th Street. For tickets, priced $100-$250, visit Telecharge.com or call (212) 239-6200 or (800) 447-7400. For benefit tickets, which include dinner with the cast, call (212) 258-3111.

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Founded in 1972 by John Houseman and Margot Harley, The Acting Company has toured 139 productions to 48 states and 10 foreign countries earning a Tony for Excellence in Theater, Obies, Audelcos and Los Angeles Critics Circle Awards.