The new show, presented by Eric Krebs and The John Houseman Theater Center in association with Castle Talent, Inc. and M. Kilburg Reedy, will open April 18.

Using no instruments other than their voices, Toxic Audio create "complex sonic textures, rhythmic drumbeats, thumping bass lines and searing guitar-like solos in their performance of contemporary pop songs, timeless classics, jazz-scat and vocally-orchestrated original compositions," according to show materials.

Jeremy James, Shalisa James, René Ruiz, Paul Sperrazza and Michelle Mailhot Valines — who comprise Toxic Audio — make their Off-Broadway debuts in Loudmouth. Ruiz directs the work.

The group has performed across the country as well as in Canada, Mexico, Asia and in the Caribbean. Toxic Audio appeared at The International New York Fringe Festival and performed alongside comedian Wayne Brady. The ensemble played a brief showcase production at the American Theater of Actors earlier this season.

The design team of Loudmouth features John A. Valines III (sound), Peter R. Feuchtwanger (scenic and lighting) and David Brooks (costumes). Loudmouth performs at the John Houseman Theater Center, located at 450 West 42nd Street (between Ninth and Tenth Avenue).