Kate Whoriskey (The Miracle Worker) will direct the 8 PM one-night-only benefit reading that will raise funds for Safe Horizon. Reckless was first produced Off-Broadway by Circle Repertory Theatre in 1988. Manhattan Theatre Club presented a Broadway revival of the play in 2004.

Ambrose (Awake and Sing!, "Six Feet Under") will play Rachel, with Esper (The Lyons, American Idiot) as Tom/Tom Jr./Man in Ski Mask, Academy Award nominee Shannon (Grace, "Revolutionary Road") as Lloyd, Najimy ("Sister Act," "Hocus Pocus") as Doctors 1-6, with Quincy Tyler Bernstine (Mr. Burns a Post Electric Play) as Pooty/Sue, Tony nominee Daniel Breaker (Shrek, Passing Strange) as Tim Timko/Roy/Talk Show Host and Miriam Shor (Hedwig, "GCB") as Trish/Woman Patient.

The evening is produced by The Indigo Theatre Project, "a theatre company that strives to unite passion with purpose by producing high-profile readings of notable plays to benefit charities aligned with the work being read." Safe Horizon is "the largest organization of its kind in the United States that helps victims overcome crisis and become survives as they restore their lives." Shoshana Feinstein and Allison Bressi also produce the reading.

Here's how it's billed: "Reckless follows the journey of Rachel (Lauren Ambrose), a housewife who discovers one fateful Christmas Eve that her husband has hired a hit-man to kill her, sending her out the window and on an unusual series of misadventures. Told with the signature dark humor of Craig Lucas, Reckless is a deeply moving story about running away from crisis and running toward yourself."

Tickets are $75. Visit ticketcentral.com or phone (212) 279-4200.