The production, which played its final performance at Off-Broadway's Theater 80 Sept. 24, will begin performances at its new venue Oct. 25.

Directed and choreographed by Christopher Gattelli, the cast will be headed by Jenn Harris, who starred in the recent Off-Broadway run. Broadway favorite Brent Barrett, who will be seen in the Chicago Shakespeare Theater's fall staging of Follies, will not continue with Silence!; his role is being recast.

Casting is expected shortly. Victoria Lang, Rich Affannato and Donna Trinkoff produce the run.

"In an effort to make the show the best it can be, the authors have trimmed some musical numbers and scenes as well as eliminating the intermission," director/choreographer Gattelli said in a statement. "In the process of moving to our new theatre, we hope that Silence! The Musical becomes a more focused production."

Silence! The Musical features a book by Tony nominee Hunter Bell and music and lyrics by Jon and Al Kaplan. In the Academy Award-winning film "The Silence of the Lambs," press notes state, "rookie FBI agent Clarice Starling matches wits with the brilliant but insane cannibal, Dr. Hannibal Lecter, to catch the serial killer known only as Buffalo Bill. Clarice must face her own demons and race the clock to unlock Lecter’s clues before another innocent girl is killed and skinned by Bill. It’s a hair-raising thriller that’s kept countless millions on the edges of their seats and permeated the pop lexicon with delightfully creepy quotes like 'I ate his liver with some fava beans and a nice Chianti' and, of course 'It places the lotion in the basket.' And now, at last, this delicate symphony of suspense has been turned on its ear and retold in the only way it can be — as a musical. A singing chorus of floppy eared lambs narrates the action; Buffalo Bill gleefully dances a hoedown while kidnapping hapless Catherine Martin; and even Dr. Lecter, scary as ever, sings about the life he’d like to lead someday outside the prison walls."

The recent production also featured musical supervision by Mark Hartman with orchestrations by Brian J. Nash, set design by three-time Tony winner Scott Pask, costume design by David Kaley, lighting design by Jeff Croiter and sound design by Carl Casella.

Tickets, priced $25-$79, are available by phoning (212) 352-3101 or by visiting SilenceTheMusical.com. P.S. 122 is located at 150 First Avenue.