Watch highlights from the first episode below:
Harris & Reese Witherspoon vs. the Skyscraper:
Michelle Kimball Gets Lucky (Episode Highlight):
Neil Goes Undercover on "The Voice" (Episode Highlight):
End of the Show Show: Don't Stop the Party:
Best Days of Your Life - Teresha and Oronde Hamilton:
"Best Time Ever with Neil Patrick Harris" airs Tuesdays at 10 PM on NBC. Starting Oct. 13 "Best Time" will move to 8 PM.
For more information, click here.