The mononymic star is currently promoting her newest film Challengers, where she stars opposite Tony nominee Mike Faist.
Other Broadway names appearing in the festival's works include Trey Parker and Matt Stone, Rosie O'Donnell, Jesse Tyler Ferguson, and more.
Tony nominee O'Hara is set to direct the feature film adaptation of his comedy, which played The Public Theatre in 2015.
The play is also eyeing a Broadway transfer next season.
Emmy winner Paul Walter Hauser will play the late Saturday Night Live actor.
The Emmy-winning actor will play Dr. Dillamond in Jon M. Chu's screen adaptation of the Broadway hit.
The film will be helmed by Todd Phillips, who produced A Star Is Born.
The Hulu comedy mystery series has featured a host of Broadway favorites since 2021.